The Role of Human Leukocyte Antigen (HLA) Complex in IBD: Crohn’s Disease and Ulcerative Colitis
نویسندگان
چکیده
The human leukocyte antigen complex on chromosome 6 is the most extensively studied genetic region in inflammatory bowel disease (IBD). Consistent evidence of linkage to IBD3 (6p21.1-23), an area which encompasses the HLA complex, has been demonstrated for both Crohn’s disease and ulcerative colitis. However, despite these efforts the HLA susceptibility genes for IBD remain elusive and unclear, a possible consequence of strong linkage disequilibrium, extensive polymorphism, high gene density across this region and different allele frequencies in several populations around the world. This article confirms the role of HLA complex genes in Crohn’s disease and ulcerative colitis susceptibility, and principally the HLA-DRB1 locus.
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